Alexia travels with her friend Marie to spend a couple of days with her family in their farm in the country. They arrive late and they are welcomed by Alexia's father. Late in the night, a sadistic and sick killer breaks into the farmhouse, slaughters Alexia's family--including their dog--and kidnaps Alexia. Marie hides from the criminal and tries to help the hysterical and frightened Alexia, chase the maniac, and disclose his identity in the end.

Cancer-terminal tycoon Peter Murdoch's secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device.

In Bucharest, Romania, the priceless breastplate of Attila, the Hun is robbed from the National Museum of Antiquities by a gang leaded by the despicable Marcus Cutter, and the curator Radu is killed by one of the thieves. Meanwhile, in New York City, the former assistant of Professor Radu, Dr. Samantha Gaines, is waiting for the valuable piece for an exhibition. The agent Jake Adams visits Samantha in the museum to tell about the heist and the death of her friend, and she tells about the legend that the breastplate would have the inscription of the location of the Sword of Mars, which is guarded by Cerberus and made Attila invincible. When Samantha's brother and addicted gambler Jack is kidnapped, she believes his debt of US$ 2,000.00 could be the reason, and travels to Romania invited by the evil kidnapper Kul Jae Sung, getting involved in a supernatural adventure with Jake.

After an undercover mission in Bucharest to disclose an international gang of weapon dealers, the agent Sonni Griffith is assigned to protect the Romanian Nadia Kaminski, the widow of an accountant of the Romanian Mafia. However, the CIA safe house is broken in by the criminals, and Sonni realizes that the information was leaked from inside the Agency. Alone, trusting only in his friend Michael Shepard, Sonni fights to survive and protect Nadia.